Hospitals & Clinics
Instrument Cleaning: Manual and automated reprocessing
Proper instrument cleaning is a critical step in the overall instrument reprocessing cycle. This task must be performed with particular care by trained and competent personnel within the Central Sterile Services Department (CSSD) of any healthcare facility.
Effective cleaning and disinfection processes significantly reduce the risk of cross-contamination between medical devices and patients, thereby contributing to the prevention of healthcare-associated (nosocomial) infections.
Thorough removal of organic and inorganic soil is essential to ensure that subsequent disinfection and sterilisation processes can achieve their intended microbiological performance.
CSSDs typically use two main methods for medical and surgical instrument cleaning:

- Manual cleaning (immersion bath / conventional hand washing)
- Automated cleaning in washer-disinfectors
In both cases, the use of an appropriate, validated detergent is mandatory to ensure effective soil removal, operator safety, and protection of instruments and equipment.
The performance of a washer-disinfector cycle depends not only on mechanical action, temperature, and water quality, but also critically on the selection of appropriate chemical detergents and process additives. The use of a correctly formulated detergent such as NOSOCLEAN is essential to achieve effective soil removal, prevent residue formation, protect instruments, and maintain washer-disinfector performance over time.
Following alkaline cleaning, the use of an acidic neutralising agent like NEUTRALKAN or CITRALKAN is recommended. Neutralisation removes alkaline residues from instrument surfaces and internal washer components, helping to prevent chemical carryover, corrosion, scale formation and long-term material damage.
Afterwards, a final rinse stage is essential to remove residual chemicals and to promote rapid, uniform drying of instruments. NOSOCLEAR is specifically formulated to optimize final rinse performance, delivering a spotless finish and enhanced drying efficiency.
Together, NOSOCLEAN, CITRALKAN / NEUTRALKAN, and NOSOCLEAR form a fully integrated automated reprocessing system designed to deliver reproducible, validated cleaning performance, enhanced process safety and optimal protection of instruments and washer-disinfectors.
Our detergents NOSOCLEAN, NOSOZYM and NOSOZYM 6 PLUS have been tested and validated according to
ISO 15883-1:2014 and ISO 15883-5:2021 for their cleaning and biofilm removal efficiency.
NOSOCLEAN is a highly concentrated and efficient alkaline detergent especially formulated for the cleaning of surgical instruments, medical equipment, ophthalmological instruments, anesthetic and endoscopic equipment, laboratory glassware and similar applications.
NOSOCLEAN is compatible with heat-resistant and heat- sensitive instruments.
NOSOCLEAN has been specially developed and gives excellent cleaning results in washers from all major brands and is very efficient in ultrasonic or immersion baths.
NOSOZYM is a highly concentrated enzymatic cleaning solution for surgical instruments and flexible endoscopes. The formulation contains a synergistic enzyme system which enzymatically degrade proteins, lipids, polysaccharides and blood residues.
NOSOZYM can be used in ultrasonic baths, automated endoscope reprocessors, washer disinfectors and immersion baths, offering flexibility across different reprocessing systems.
NOSOZYM is compatible with all major brands of endoscopes and approved by PENTAX MEDICAL®
NEUTRALKAN is an acidic detergent. It is a highly concentrated combination of organic and inorganic acids. It removes limescale, rust stains and mineral deposits off the instruments as well as the inside walls of the washer disinfectors.
NEUTRALKAN is compatible with stainless steel instruments, ophtalmological instruments, anesthetic equipment, laboratory glassware, hard plastics and all acid resistant medical devices.
CITRALKAN is an acidic detergent for the neutralization of alkaline deposits in washer disinfectors and/or acidic pre-cleaning of instruments and laboratory glassware.
CITRALKAN removes limescale, rust stains and mineral deposits off the instruments as well as the inside walls of the washer disinfectors.
NOSOCLEAR is a highly concentrated rinse aid specifically formulated for fast, spot-free drying of surgical instruments, laboratory glassware and other sensitive medical devices in automated reprocessing systems.
NOSOCLEAR is intended for use in washer-disinfectors, cart washers, tunnel washers, and other automated instrument reprocessing equipment.
MEDALKAN – The Next Generation of Medical Disinfectants

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